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Aerosol-generating procedures (AGPs) are medical practices that create aerosolized particles, which can contain infectious agents and pose a risk of transmission, especially in the context of respiratory illnesses. These procedures involve the manipulation of airways, lungs, or respiratory passages, resulting in the release of tiny droplets or aerosols into the air. AGPs are often performed in medical settings, such as hospitals, during emergencies, or in the context of respiratory therapy and can include interventions like intubation, extubation, nebulization, and non-invasive ventilation. The definition of AGPs encompasses any medical procedure that is likely to generate aerosols that may carry pathogens, thereby raising concerns for healthcare workers and others present in the vicinity. In recent years, with the emergence of highly transmissible respiratory viruses, such as SARS-CoV-2, the virus responsible for COVID-19, awareness of the risks associated with AGPs has intensified. Healthcare facilities have had to develop stringent protocols to minimize exposure risks, such as implementing personal protective equipment (PPE) requirements, utilizing negative pressure rooms, and ensuring proper ventilation to reduce the concentration of aerosols in the air. It is crucial to recognize that while aerosols can be produced during these procedures, the actual risk of transmission depends on various factors, including the type of procedure, the infectious status of the patient, and the environment in which the procedure is conducted. Understanding which procedures are classified as aerosol-generating is essential in planning appropriate infection control measures. For example, respiratory therapy techniques that utilize nebulizers can aerosolize medication, potentially disseminating pathogens into the air. Similarly, endotracheal intubation is a high-risk AGP, as it involves inserting a tube into the trachea, often performed on patients with compromised respiratory function. Given the potential consequences of AGPs, healthcare providers must be vigilant in assessing the need for such procedures, weighing the benefits against the associated risks, especially in the presence of infectious diseases. In addition to healthcare workers, patients in shared spaces also face risks from aerosol exposure. This has led to increased emphasis on patient isolation and triage during times of widespread respiratory illness, ensuring that those undergoing AGPs are in controlled environments where aerosol transmission can be limited. Educational initiatives have focused on equipping medical staff with knowledge regarding best practices and risk mitigation strategies when performing AGPs. These include optimizing the timing of procedures, using alternative strategies when feasible, and employing the highest level of precaution during high-risk situations. As our understanding of aerosol dynamics and transmission pathways continues to evolve, ongoing research remains essential to refining guidelines and maintaining safety in healthcare settings. Ultimately, addressing the challenges posed by aerosol-generating procedures requires a multidisciplinary approach that prioritizes patient safety while safeguarding healthcare workers' health. This balance is crucial in providing effective medical care without increasing the risk of infectious disease transmission within healthcare environments.